So, the metabolite is responsible for about twenty% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly inside the feces (about eighty% of administered oral dose) and also to a lesser extent during the urine (close to thirteen% in the administered oral dose). If taken which has a large-Fats meal, absorption is diminished; time taken to achieve the maximum plasma concentration increases by about 1 hour, and the maximum focus by itself is reduced by practically 1-3rd.[fifty two]
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakningen og pakningsvedlegget nøye før bruk. Her kan du finne mer informasjon om Viagra Reseptfri og impotens.
Having said that, because bigger plasma ranges may improve the incidence of adverse reactions, a beginning dose of twenty five mg ought to be regarded in more mature topics because of the upper systemic exposure [see DOSAGE AND ADMINISTRATION].
Denne medisinen skal kun brukes av menn. Dette fordi det foreløpig ikke foreligger nok forskningsresultater om hvordan potenspiller virker på kvinner og hvilke bivirkninger som kan forekomme.
The necessarily mean continuous state quantity of distribution (Vss) for sildenafil is one hundred and five L, indicating distribution in the tissues. Sildenafil and its big circulating N-desmethyl metabolite are both of those about ninety six% certain to plasma proteins. Protein binding is unbiased of whole drug concentrations.
Doctors should really advise individuals with the potential for VIAGRA to augment the blood pressure level decreasing result of alpha-blockers and anti-hypertensive medicines. Concomitant administration of VIAGRA and an alpha-blocker may perhaps result in symptomatic hypotension in some patients.
Denne potenspillen er en behandling for menn som lider av erektil dysfunksjon (impotens) det vil si, manglende evne til å oppnå eller opprettholde en ereksjon som varer lenge nok for tilfredsstillende seksuell nytelse.
Stronger CYP3A4 inhibitors for example ketoconazole or itraconazole could be expected to own bigger effects than observed with saquinavir. A starting up dose of 25 mg of VIAGRA more info really should be regarded in sufferers using erythromycin or powerful CYP3A4 inhibitors (like saquinavir, ketoconazole, itraconazole) [see DOSAGE AND ADMINISTRATION, CLINICAL PHARMACOLOGY].
Really serious coronary heart indications which include quick, irregular, or pounding heartbeats; fluttering inside your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
The AUC of your Energetic metabolite, N-desmethyl sildenafil, was amplified 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These consequences around the metabolite are usually not predicted to be of medical consequence.
This doc isn't going to contain all doable Unwanted side effects and Many others may possibly occur. Check out with all your health practitioner for additional details about Negative effects.
Nosebleeds. Sildenafil may well result in nosebleeds. You may well be at larger hazard for this if you are taking a blood thinner medicine. Notify your Health care provider if you obtain nosebleeds often although getting sildenafil. Should your nosebleed is critical or will not cease soon after making use of strain, get support without delay.
In cases of overdose, common supportive steps should be adopted as expected. Renal dialysis just isn't predicted to speed up clearance as sildenafil is extremely certain to plasma proteins and it is not eliminated within the urine.
Medical professionals must think about regardless of whether their individuals with fundamental NAION threat factors may very well be adversely impacted by usage of PDE5 inhibitors. People who have already seasoned NAION are at amplified risk of NAION recurrence. As a result, PDE5 inhibitors, together with VIAGRA, ought to be made use of with warning in these patients and only when the expected benefits outweigh the dangers.